Ozempic Nausea: Why It Happens and How to Find Relief

If you’ve started a GLP-1 like Ozempic (semaglutide) and find yourself battling bouts of nausea, you’re not alone. Many people experience this side effect, especially soon after starting Ozempic or increasing the dosage. The good news is that there are ways to help settle your stomach and relieve nausea from semaglutide and GLP-1s. 

Why can Ozempic cause nausea?

Ozempic belongs to a class of medications called GLP-1 receptor agonists. These medications slow digestion and help you feel fuller for longer, which supports weight loss. But because food stays in your stomach longer, Ozempic can also cause nausea. 

How long does nausea last with Ozempic?

Nausea is typically most noticeable during the first few weeks after starting Ozempic or increasing your dose. Many people report improvements in nausea as their body adjusts to the medication, usually within a few weeks. 

If your nausea is severe, prolonged or worsening, talk to your healthcare provider. 

What to eat on Ozempic to avoid nausea

Your food choices play a big role in how your stomach feels on Ozempic. Here’s what tends to help and what to avoid. 

• Eat smaller, more frequent meals. Grazing prevents overfilling your stomach. 
• Eat bland foods to settle your stomach. Simple foods like broth-based soups, plain Greek yogurt or poached chicken can help prevent worsening nausea. 
• Consume hydrating foods. Dehydration can make nausea worse, so opt for water, broth, cucumber, tomatoes and other hydrating foods. 
• Avoid rich, spicy or greasy foods. Heavy foods can linger in your stomach longer, making your nausea worse. Spicy meals, creamy sauces and fried foods are common triggers.
• Prioritize healthy plant oils. Healthy plant oils that are liquid at room temperature such as olive and avocado oils tend to be better tolerated than solid fats such as butter, lard or other saturated animal fats.

How to Find Ozempic Nausea Relief

• Go low and slow on Ozempic dose. Always follow your prescriber’s guidance. 
• Don’t rush through meals. Eating slowly prevents overloading your stomach and can support healthy digestion. 
• Don’t lie down after eating. Stay upright for at least an hour after your meal. 
• Remove foods that worsen Ozempic side effects. Carbonated drinks, alcohol, spicy foods, fried foods and rich desserts can trigger nausea. 
• Adjust injection timing. Some people find it helpful to take Ozempic before bed, while others feel better taking it in the morning. Talk to your provider about the right timing for you. 
• Consider peppermint or ginger. Natural sugar-free remedies like peppermint tea or ginger tea may help relieve nausea. 
• Consider anti-nausea medication. Talk to your healthcare provider to see if you may benefit from an anti-nausea medication. 

Ozempic Nausea FAQs

Is it normal to feel sick with Ozempic?

Yes, it’s normal to feel Ozempic side effects, especially if you have just started Ozempic or recently increased your dose. 

Can certain foods or sugar trigger more nausea?

Yes. Spicy, greasy or fatty foods can all trigger nausea. 

Where to inject Ozempic to avoid nausea?

Your injection site doesn’t typically affect nausea. 

‍Does time of day (morning vs. evening) affect nausea from Ozempic?

Some people find they experience fewer symptoms when they take Ozempic at night, but your timing should be based on your provider’s recommendations and your lifestyle.

‍Does starting at a lower dose help with nausea?

Yes. Starting with a lower dose is one of the best ways to reduce side effects. 

‍What helps with Ozempic nausea relief?

Simple remedies like sipping ginger or peppermint tea, eating bland snacks, and staying hydrated can provide relief. Some people find light walks after meals helpful. If nausea persists, your doctor may recommend adjusting your dose or prescribing an anti-nausea medication.

Does the nausea from Ozempic go away or come back with each dose change?

Sometimes side effects can flare when you increase your dose, but they should improve as your body adapts. 

When to call your doctor

Call your healthcare provider if you experience:

• Severe or prolonged nausea or vomiting, especially if you have a hard time keeping down fluids 
• Persistent abdominal pain 
• Dizziness
• Dark urine
• Weakness

Many people find that nausea from Ozempic improves over time. By making a few small changes to your eating habits and daily routine, you can stay on track with treatment and feel better along the way. 

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